Sedation and impairment of performance are concerns when sedating antihistamines are used, but these adverse effects may diminish after 1-2 weeks of therapy.
Many patients find that pruritus is less troublesome during the day but is maximized at night, when there are fewer distractions.
Application of lotions with menthol and phenol provide prompt relief of pruritus for some patients.
Low-sedation antihistamines decrease the intensity of hives and pruritus in patients with mild chronic urticaria and are considered first-line therapy.
Patients with severe hepatic (liver) disorders may need to start with a lower dose.They both calm your immune system’s reaction to allergens. They also take effect at different times and stay effective for different durations. Antihistamines have a reputation of making you sleepy because the first types crossed into your central nervous system more easily and had a direct effect on your alertness.These factors could determine which of these two drugs is better for you. However, newer antihistamines like Zyrtec and Claritin are less likely to cause this side effect. Most people experience at least 24 hours of relief after a single dose. People who take it may feel relief in as little as one hour.Substances that act as inhibitors of the CYP3A4 enzyme such as ketoconazole, erythromycin, cimetidine, and furanocoumarin derivatives (found in grapefruit) lead to increased plasma levels of loratadine.This had clinically significant effects in controlled trials of higher-than-usual doses of loratadine (20 mg).Clarityn allergy tablets and Clarityn rapide allergy tablets both contain the active ingredient loratadine, which is a type of medicine called a non-sedating antihistamine.Loratadine works by preventing the actions of histamine - a substance produced by the body when it reacts to a foreign substance, such as pollen or pet fur (these are known as allergens).Among the most popular over-the-counter (OTC) allergy meds are Zyrtec and Claritin.These two allergy drugs produce very similar results. Both cetirizine and loratadine are nonsedating antihistamines.Blocking the actions of histamine relieves the itching and reduces the rash associated with this condition and other allergic skin reactions.Medicines and their possible side effects can affect individual people in different ways.